Paul A McEwan Selected Research

emt protein-tyrosine kinase (IL2-inducible T-cell kinase)

12/2016	Fragment Molecular Orbital Method Applied to Lead Optimization of Novel Interleukin-2 Inducible T-Cell Kinase (ITK) Inhibitors.
5/2015	Tetrahydroindazoles as Interleukin-2 Inducible T-Cell Kinase Inhibitors. Part II. Second-Generation Analogues with Enhanced Potency, Selectivity, and Pharmacodynamic Modulation in Vivo.
7/2014	Property- and structure-guided discovery of a tetrahydroindazole series of interleukin-2 inducible T-cell kinase inhibitors.

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Paul A McEwan Research Topics

Disease

3	Asthma (Bronchial Asthma) 12/2016 - 07/2014
2	Thrombosis (Thrombus) 04/2010 - 11/2009
1	Hemorrhage 04/2010
1	Tuberculosis (Tuberculoses) 12/2006

Drug/Important Bio-Agent (IBA)

3	emt protein-tyrosine kinase (IL2-inducible T-cell kinase)IBA 12/2016 - 07/2014
2	Interleukin-2 (IL2)IBA 05/2015 - 07/2014
2	T-Cell Antigen Receptors (T-Cell Receptor)IBA 05/2015 - 07/2014
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 12/2016
1	Tyrosine (L-Tyrosine)FDA Link 07/2014
1	Phosphotransferases (Kinase)IBA 07/2014
1	Factor IX (Coagulation Factor IX)FDA LinkGeneric 04/2010
1	Enzyme Precursors (Zymogens)IBA 04/2010
1	EnzymesIBA 04/2010
1	Factor XI (Plasma Thromboplastin Antecedent)IBA 04/2010
1	von Willebrand FactorIBA 11/2009
1	Platelet Membrane GlycoproteinsIBA 11/2009
1	ThioredoxinsIBA 12/2006
1	Oxygen (Dioxygen)IBA 12/2006
1	NitrogenIBA 12/2006